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Subject: Re: [DCHAS-L] Handling/washing Masks-VIral Particles or Aerosols after wearing?
Date: Wednesday, July 8, 2020 at 9:32:08 PM
Author: Domenic DeCaria <ddecaria**At_Symbol_Here**VINYLINFO.ORG> 		Next by Date:
Subject: [DCHAS-L] Oxygen Deficient Calculations?
Date: Thu, 9 Jul 2020 14:31:16 +0000
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From: DCHAS Membership Chair <membership**At_Symbol_Here**DCHAS.ORG>
Subject: [DCHAS-L] Serious Explosion during Large-Scale Preparation of an Amine by Alane (AlH3) Reduction of a Nitrile Bearing a CF3 Group
Date: Thu, 9 Jul 2020 07:48:32 -0400
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Message-ID: 18547431-8C47-4C5C-8D6E-C961A7E8FDA1**At_Symbol_Here**dchas.org


Serious Explosion during Large-Scale Preparation of an Amine by Alane (AlH3) Reduction of a Nitrile Bearing a CF3 Group

https://pubs.acs.org/doi/10.1021/acs.chas.0c00045

Here, we wish to report a serious explosion during large-scale preparation of an amine by alane (AlH3) reduction of a nitrile bearing a CF3 group. The accident took place during the reduction of a 1 mol batch of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile. At the stage of decomposition of the reaction mixture after reduction with MeOH, the reactor was destroyed by detonation; one researcher was seriously harmed by shatters and burnt by flames. This Case Study describes this incident in detail and discusses how we can prevent similar incidents.

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