Few more articles about the rxn. Scale-up.

 

https://pubs.acs.org/doi/10.1021/op4002033

https://pubs.acs.org/doi/pdf/10.1021/cs400553t

https://pubs.acs.org/doi/10.1021/cen-09247-notw8

https://pubs.acs.org/doi/pdf/10.1021/op300171m

 

Tilak

Tilak Chandra, Ph.D.

Chemical Safety Specialist

UW-Madison

tilak.chandra**At_Symbol_Here**wisc.edu

Ph. 608-890-0255

       608-622-9761 (Cell)

 

"--our job in safety is to make the task happen, SAFELY; not to interfere with the work-" Neal Langerman

 

 

 

From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU> On Behalf Of Orella, Charles J
Sent: Tuesday, September 25, 2018 10:32 AM
To: DCHAS-L**At_Symbol_Here**PRINCETON.EDU
Subject: Re: [DCHAS-L] Papers on risks of scaling up reactions

 

Jeff,

 

Try these links, they are mostly classic papers from process safety literature.  These papers primarily focus on thermal runaway and pressure generation that can lead to catastrophic equipment failure.  They don't address issues of occupational exposure to chemicals.

 

Recommended Literature for Process Safety

 

Note:  Recommend documents 2, 3, and 5 as introductory literature

 

Thermal Risk Evaluation

 

1.       Chemical Rxn Engineering Safety Gygax 1988 - http://ac.els-cdn.com/0009250988870404/1-s2.0-0009250988870404-main.pdf?_tid=ce637eea-8906-11e7-8044-00000aacb360&acdnat=1503604978_df54e7b9c5c122afb38c6b5d06dc6e19

 

2.     Townsend, Thermal hazard evaluation by an accelerating rate calorimeter; https://www.sciencedirect.com/science/article/pii/0040603180850015

 

3.     Stoessel review in OPRD_1997: http://pubs.acs.org/doi/pdfplus/10.1021/op970016i

 

4.     Stoessel Planning protection measures against runaway reactions using criticality classes 2009: http://ac.els-cdn.com/S0957582008001134/1-s2.0-S0957582008001134-main.pdf?_tid=8414813e-8908-11e7-aa92-00000aacb360&acdnat=1503605712_0394a33b0b60648ce109bfb84b79f088

 

5.     Selection of the Proper Calorimetric Test Strategy in Reactive Chemicals Hazard Evaluation, Frurip (Dow Chemical) - OPRD 2008 -  http://pubs.acs.org/doi/pdf/10.1021/op800121x

 

 

Pressure Relief Evaluation

 

6.       Fauske Monogram 1984 Generalized Vent Sizing Monogram for Runaway Chemical Reactions: https://cdn2.hubspot.net/hubfs/232514/Fauske-2017/PDF/GeneralizedVentSizingNomogramforRunnawayChemicalReactions_0.pdf?t=1503591010230

 

7.     Comparison of pressure-relief calculation methods;  https://cdn2.hubspot.net/hubfs/232514/Fauske-2017/PDF/IntroducingPrEVent-PracticalEmergencyVentSizingSoftware.pdf?t=1495047142584  - list of original references for models and data

 

Training Sources (2017)

A.     AIChE DIERS training http://www.iomosaic.com/diersweb/courses.aspx

 

B.     CCPS https://www.aiche.org/ccps; https://www.aiche.org/academy/

 

C..     Dekra Course Calendar:  https://www.dekra-process-safety.com/process-safety-academy

 

D.    Fauske Training https://www.fauske.com/training

 

E.    Mettler Toledo Training course list (live & web) https://www.mt.com/hk/en/home/perm-lp/product-organizations/ana/ta-etraining.html

 

F.     Iomosaic Training - http://www.iomosaic.com/training/available-courses

 

 

Best, chuck

From: ACS Division of Chemical Health and Safety [mailto:DCHAS-L**At_Symbol_Here**PRINCETON.EDU] On Behalf Of Jeffrey R. Cogswell
Sent: Tuesday, September 25, 2018 11:04 AM
To: DCHAS-L**At_Symbol_Here**PRINCETON.EDU
Subject: [DCHAS-L] Papers on risks of scaling up reactions

 

EXTERNAL EMAIL - Use caution with any links or file attachments.

Hello

I'm currently working on a safety talk about RAMP and decided to include a section on "RAMPing up Reactions"

It was discussed at ACS that scaling up reactions is a under-stated danger in many chemistry laboratories.

 

Does anyone have any suggestion for articles that talks about or quantifies the risks of increasing the yield in chemical reactions?

 

For example: https://ac.els-cdn.com/S1871553213006178/1-s2.0-S1871553213006178-main.pdf?_tid=672cf49d-0170-4ff1-8b06-85bc88bda807&acdnat=1537887055_4baf3ea46cec9ef7b4cb51c2aba76bf8 I found very informative and it would be great to find more sources.

 

Thanks

 

Jeffrey R. Cogswell, Ph.D.

Chemical Inventory and Laboratory Resource Center Technician, EHS

37 Dewey Field Road, HB 6216

Hanover, New Hampshire 03755

http://www.dartmouth.edu/~ehs/

 

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