Hi Tilak and all,

 

So I was thinking about it more from the standpoint of nucleophilic reagents generating fluoride anion and being in the lipophilic environment of the reaction or from having other organic materials present (including the cationic portion of the reagent itself).  I would think that those conditions would lead to the same deep tissue exposure potential of fluoride that makes HF so insidious.  Certainly under appropriate conditions these could generate HF, so there is that issue as well.  Electrophilic fluorination reagents would not pose the same threat because they would not generate fluoride anion.  The document from the Baran group below shows many different types of fluorination reagents, and is not specific to nucleophilic reagents.

 

Common examples of nucleophilic fluorination reagents include pyridine hydrofluoride, DAST, and even sodium or potassium fluoride in the presence of crown ethers to increase solubility and fluoride availability.

 

Just curious if anyone has developed programs for these, or knew of any exposures.

 

Thanks,

 

Kristi

 

 

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