We routinely task the toxicologists in our cheminformatics group to carry out hazard assessments to assign GHS classifications for our Research Safety Data Sheets. They
integrate information from the public domain, QSAR tools and business information into an overall hazard assessment to more accurately assign hazard classifications for novel chemicals.
Pam
Pamela J. Spencer, Ph.D., D.A.B.T.
Scientific Director, TERC
The Dow Chemical Company
Midland MI 48674
Telephone: (989) 636-9797
Fax: (989) 638-9863
Email: pjspencer**At_Symbol_Here**dow.com
From: DCHAS-L Discussion List [mailto:dchas-l**At_Symbol_Here**med.cornell.edu]
On Behalf Of Mike Fisher
Sent: Tuesday, October 13, 2015 9:42 AM
To: DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU
Subject: Re: [DCHAS-L] Assessing and predicting the health hazards of newly synthesized compounds for the development of SDSs.
I believe we’ve had clients utilize our toxicologist consultants for this purpose.
Greetings:
What do others do to assess, predict and assign an OSHA 2012 health hazard classification to a newly synthesize compound develop by your
home institution when you are required to develop a SDS?
I'm not so concerned about assessing the hazards of mixtures of known chemicals but concerned more about new compounds, where the new
compound has no history of a health hazard evaluation and where using the precursor chemicals is not as reliable predictor of its health hazards/toxicity.
Does anyone use a toxicologist to review the chemical structure of the new compound to predict and present their "best judgment" regarding
the health hazard classifications?
Sincerely,
Steve Rupkey, CIH
Argonne National Laboratory
srupkey**At_Symbol_Here**anl.gov
