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Previous by Date: Subject: Re: toxicity question Date: Fri, 11 Jun 2010 16:45:21 -0500 Author: "Tsiakals, Nicholas John" |
Next by Date: Subject: Re: toxicity question Date: Fri, 11 Jun 2010 16:34:00 -0600 Author: Alan Hall |
Nick et al,
I'm not sure that was what I'm saying. I'm a Medical Toxicologist
, not a medicinal or any other type of chemist.
What you have with any medication which may be in a salt form, the dose o
f the active component in a given volume may be different based on the salt
form. The therapeutic dose may therefore differ, and the way in
which the active component can be safely and efficaciously given may differ
.
The solubility may or may not have anything do do with it. Don't le
t's get each other wrong. You'd have to discuss the the diluent,
and excipients, and a whole bunch of other issues for each compound.
; This is not one in which a simple answer, chemistry or medicine, or
toxicology would necessarily be correct in all cases.
Alan
Alan H. Hall, M.D.
Sounds like you=92re saying that co mparing the solubility of one salt to another plays a part in that overall dosing question.
That helps, Alan. Thanks!
-Nick
From: DCHAS-L Discussion List [mailto:DCHAS
-L**At_Symbol_Here**LIST.UVM.EDU] On Behalf Of Alan Hall
Sent: Friday, Ju
ne 11, 2010 9:41 AM
To: DCHAS-L**At_Symbol_Here**LIST.UVM.EDU
Subject:
Re: [DCHAS-L] toxicity question
Nick et al,
In general, the toxici
ty would not change with the salt involved, although there are exc
eptions. For example, when treating hydrofluoric acid (HF) exposu
res with calcium salts, the calcium gluconate salt can be used topically
, injected intradermally, or given intravenously or interarterially.&nb
sp; However, the calcium chloride salt can only be injected intravenous
ly, because it causes severe skin damage and sloughing if extravasated fr
om a vein or injected intradermally and can cause devastating vascular inju
ry if injected intraarterially.
Calcium salt
s are also a good example of the second point. The dose of the acti
ve ingredient can vary significantly with the same volume of different salt
s. In the calcium example, the calcium chloride salt in a
given volume will have approximately 3 times more Ca+2 ion that the same vo
lume of the calcium gluconate salt. When treating life-threatening
cardiovascular complications of hydrofluoric acid systemic toxicity, it i
s therefore often wise to choose the calcium chloride salt for intravenous
infusion (with precautions against extravaasation), as a much higher dose
of calcium ion can provided with the same volume and the same infusion tim
e.
A similar comparison might be made for norepinephrine,
but what the relationship of dose is between various salt forms in the same
volume, I don't have memorized.
Hope this answers the que
stion.
Alan
Alan H. Hall, M.D.
President and
Chief Medical Toxicologist
Toxicology Consulting and Medical Translating
Services, Inc.
Laramie, WY
Clinical Assistant Profes
sor
Colorado School of Public Health
Denver, CO
>
; Date: Thu, 10 Jun 2010 16:30:45 -0500
> From: tsiakals**At_Symbol_Here**ILLINO
IS.EDU
> Subject: [DCHAS-L] toxicity question
> To: DCHAS-L
**At_Symbol_Here**LIST.UVM.EDU
>
> Good afternoon all,
>
>
; How does toxicity compare from one pharmaceutical salt to another? More
specifically, is the toxicity of norepinephrine the same as norepinephri
ne bitartrate salt?
>
> Thanks,
> -Nick
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